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Platelet-derived microparticles (PDMPs) are small vesicles released from activated platelets and have been found to be increased in cardiovascular disease and to predict the severity of acute coronary syndromes. The major agonist for PDMP generation is thrombin. Platelets, therefore, are likely to be important sources of PDMPs. Recently, we showed that in thrombin-stimulated whole blood, platelet-derived microparticles were clearly detectable by flow cytometry (FCM) in comparison to assays based on particle sedimentation and platelet counts. In the present study, we have applied this novel assay to assess platelet function before and after the administration of clopidog 0b46394aab